It’s not recommended and not required to change the default location of the OST file. But if you think you can save some storage space by relocating the OST file, you can do it.
When you are using Outlook with an Exchange account, your mailbox and other data resides on the Exchange Server. But enabling the Cached Exchange Mode helps you work even when you are not connected to Exchange. It’s offline Outlook Data (OST) file, a local copy of your Exchange mailbox, that helps you use the mailbox even you are offline. The default locations of OST file are:
Changing the location of OST file basically involves disabling the Cached Exchange Mode, configuring a new location for the OST file, and then re-enabling the Cached Exchange Mode so that a new OST fill be created in the newly configured location. The new OST file will download all the mailbox data from Exchange data automatically. This is how you can do it in Outlook 2010:
Why you need not move the OST file to another computer?
You need not move your OST file to another computer to use Outlook there. When you add your account to the Outlook there and enable Cached Exchange Mode, a new OST file is created where you can get all your data.
Also, there is no need of keeping backups for OST file as Exchange can create them afresh. However, after Exchange Server disasters and crashes, one can recover their mailbox data and convert OST to PST file easily. One can use third-party tools like Kernel for OST to PST to convert OST files to PST format.
Outlook users can change the default location of the OST file if they want to do so. However, there is no need for them to back up OST files or port OST file from one computer to another as Exchange can recreate them. But at the time of Exchange disasters or crashes, users can convert OST files to PST using third-party tools like Kernel for OST to PST to recover its data.
TechNet Expert Reviews on OST to PST Converter tool